The disease, which, according to the FDA, affects one in every 40,000 people in the U.S., is characterized by loss of motor and cognitive function and early death
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TNF- can induce synovial cells to express intercellular adhesion molecule-1 (ICAM-1), making it easier for immune cells to adhere and transmigrate across endothelial cells into the synovium (147)
It works in tandem with an enzyme called glutathione peroxidase (GPx) to clear toxic peroxides from the cell
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